Publications Resulting from CFRI's Elizabeth Nash Memorial Fellowship
Chandy, G., M. Grabe, H. P. Moore and T. E. Machen. Proton leak and CFTR in regulation of Golgi pH in respiratory epithelial cells. Am J Physiol Cell Physiol 281:C908-921, 2001.
Machen, T. E., G. Chandy, M. Wu, M. Grabe and H. P. Moore. Cystic fibrosis transmembrane conductance regulator and H+ permeability in regulation of Golgi pH. Jop 2:229-236, 2001.
Jacob, T., R. J. Lee, J. N. Engel and T. E. Machen. Modulation of cytosolic Ca(2+) concentration in airway epithelial cells by Pseudomonas aeruginosa. Infect Immun 70:6399-6408, 2002.
Howard, M., H. Fischer, J. Roux, B. C. Santos, S. R. Gullans, P. H. Yancey and W. J. Welch. Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function. J Biol Chem 278:35159-35167, 2003.
Frank, J., J. Roux, H. Kawakatsu, G. Su, A. Dagenais, Y. Berthiaume, M. Howard, C. M. Canessa, X. Fang, D. Sheppard, M. A. Matthay and J. F. Pittet. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem 278:43939-43950, 2003.
Swanson, B., R. Savel, F. Szoka, T. Sawa and J. Wiener-Kronish. Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods 52:361-366, 2003.
Chen, Y., Y. H. Zhao, T. B. Kalaslavadi, E. Hamati, K. Nehrke, A. D. Le, D. K. Ann and R. Wu. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. Am J Respir Cell Mol Biol 30:155-165, 2004.
Fischer, H., C. Schwarzer and B. Illek. Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A 101:3691-3696, 2004.
Schwarzer, C., T. E. Machen, B. Illek and H. Fischer. NADPH oxidase-dependent acid production in airway epithelial cells. J Biol Chem 21:21, 2004.
Tong, Z., B. Illek, V. J. Bhagwandin, G. M. Verghese and G. H. Caughey. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. Am J Physiol Lung Cell Mol Physiol 9:9, 2004.
Verghese, G. M., Z. Y. Tong, V. Bhagwandin and G. H. Caughey. Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol 30:519-529, 2004.
Wang, X. F., M. M. Reddy and P. M. Quinton. Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts. Exp Physiol 89:417-425, 2004.
Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J. 19:287-9, 2004
Salinas, DB, Pedemonte N, Muanprasat C, Finkbeiner WR, Nielson DW, Verkman AS. CFTR involvement in nasal potential differences in mice an pigs studied using a thiazolidinone CFTR inhibitor, Am J Physiol 287:L936-43, 2004
Salinas, D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 19:431-3, 2004
Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D MA, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-submit in alveolar epithelial cells via a p38 MAPK- dependent signaling pathway. J Biol Chem. 280:18579-89, 2005
Pittet, JF, Lee H, Pespeni M, O’Mahony A, Roux J, Welch. Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. J Immunol. 174:384-94, 2005
Wang X, Lytle C, Quinton PM. Predominant constitutive CFTR conductance in small airways. Respir Res 6:7 (12pp), 2005
Chandy, G., M. Grabe, H. P. Moore and T. E. Machen. Proton leak and CFTR in regulation of Golgi pH in respiratory epithelial cells. Am J Physiol Cell Physiol 281:C908-921, 2001.
Machen, T. E., G. Chandy, M. Wu, M. Grabe and H. P. Moore. Cystic fibrosis transmembrane conductance regulator and H+ permeability in regulation of Golgi pH. Jop 2:229-236, 2001.
Jacob, T., R. J. Lee, J. N. Engel and T. E. Machen. Modulation of cytosolic Ca(2+) concentration in airway epithelial cells by Pseudomonas aeruginosa. Infect Immun 70:6399-6408, 2002.
Howard, M., H. Fischer, J. Roux, B. C. Santos, S. R. Gullans, P. H. Yancey and W. J. Welch. Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function. J Biol Chem 278:35159-35167, 2003.
Frank, J., J. Roux, H. Kawakatsu, G. Su, A. Dagenais, Y. Berthiaume, M. Howard, C. M. Canessa, X. Fang, D. Sheppard, M. A. Matthay and J. F. Pittet. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem 278:43939-43950, 2003.
Swanson, B., R. Savel, F. Szoka, T. Sawa and J. Wiener-Kronish. Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods 52:361-366, 2003.
Chen, Y., Y. H. Zhao, T. B. Kalaslavadi, E. Hamati, K. Nehrke, A. D. Le, D. K. Ann and R. Wu. Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues. Am J Respir Cell Mol Biol 30:155-165, 2004.
Fischer, H., C. Schwarzer and B. Illek. Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A 101:3691-3696, 2004.
Schwarzer, C., T. E. Machen, B. Illek and H. Fischer. NADPH oxidase-dependent acid production in airway epithelial cells. J Biol Chem 21:21, 2004.
Tong, Z., B. Illek, V. J. Bhagwandin, G. M. Verghese and G. H. Caughey. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. Am J Physiol Lung Cell Mol Physiol 9:9, 2004.
Verghese, G. M., Z. Y. Tong, V. Bhagwandin and G. H. Caughey. Mouse prostasin gene structure, promoter analysis, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol 30:519-529, 2004.
Wang, X. F., M. M. Reddy and P. M. Quinton. Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts. Exp Physiol 89:417-425, 2004.
Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J. 19:287-9, 2004
Salinas, DB, Pedemonte N, Muanprasat C, Finkbeiner WR, Nielson DW, Verkman AS. CFTR involvement in nasal potential differences in mice an pigs studied using a thiazolidinone CFTR inhibitor, Am J Physiol 287:L936-43, 2004
Salinas, D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 19:431-3, 2004
Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D MA, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-submit in alveolar epithelial cells via a p38 MAPK- dependent signaling pathway. J Biol Chem. 280:18579-89, 2005
Pittet, JF, Lee H, Pespeni M, O’Mahony A, Roux J, Welch. Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. J Immunol. 174:384-94, 2005
Wang X, Lytle C, Quinton PM. Predominant constitutive CFTR conductance in small airways. Respir Res 6:7 (12pp), 2005