CFRI and the Elizabeth Nash Memorial Fellowship for Post-Doctoral Research in CF
In August of 2003, Cystic Fibrosis Research, Inc. (www.cfri.org) re-named their fellowship program to
honor Liz, her work in CF research, and her service as chairperson of the CFRI research advisory
committee. The Elizabeth Nash Memorial Fellowship program is designed to encourage post-doctoral
fellows to pursue careers in CF research and is awarded annually to scientists in the San Francisco
Bay Area. A list of papers published to date through this funding is included below.
Publications Resulting from Funding via CFRI's Elizabeth Nash Memorial Fellowship
Chandy, G., M. Grabe, H. P. Moore and T. E. Machen. Proton leak and CFTR in regulation of Golgi pH
in respiratory epithelial cells. Am J Physiol Cell Physiol 281:C908-921, 2001.
Machen, T. E., G. Chandy, M. Wu, M. Grabe and H. P. Moore. Cystic fibrosis transmembrane
conductance regulator and H+ permeability in regulation of Golgi pH. Jop 2:229-236, 2001.
Jacob, T., R. J. Lee, J. N. Engel and T. E. Machen. Modulation of cytosolic Ca(2+) concentration in
airway epithelial cells by Pseudomonas aeruginosa. Infect Immun 70:6399-6408, 2002.
Howard, M., H. Fischer, J. Roux, B. C. Santos, S. R. Gullans, P. H. Yancey and W. J. Welch.
Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane
conductance regulator (CFTR) protein maturation and function. J Biol Chem 278:35159-35167, 2003.
Frank, J., J. Roux, H. Kawakatsu, G. Su, A. Dagenais, Y. Berthiaume, M. Howard, C. M. Canessa, X.
Fang, D. Sheppard, M. A. Matthay and J. F. Pittet. Transforming growth factor-beta1 decreases
expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid
transport via an ERK1/2-dependent mechanism. J Biol Chem 278:43939-43950, 2003.
Swanson, B., R. Savel, F. Szoka, T. Sawa and J. Wiener-Kronish. Development of a high throughput
Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods 52:361-366, 2003.
Chen, Y., Y. H. Zhao, T. B. Kalaslavadi, E. Hamati, K. Nehrke, A. D. Le, D. K. Ann and R. Wu.
Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular
tissues. Am J Respir Cell Mol Biol 30:155-165, 2004.
Fischer, H., C. Schwarzer and B. Illek. Vitamin C controls the cystic fibrosis transmembrane
conductance regulator chloride channel. Proc Natl Acad Sci U S A 101:3691-3696, 2004.
Schwarzer, C., T. E. Machen, B. Illek and H. Fischer. NADPH oxidase-dependent acid production in
airway epithelial cells. J Biol Chem 21:21, 2004.
Tong, Z., B. Illek, V. J. Bhagwandin, G. M. Verghese and G. H. Caughey. Prostasin, a membrane-
anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway
epithelial cell line. Am J Physiol Lung Cell Mol Physiol 9:9, 2004.
Verghese, G. M., Z. Y. Tong, V. Bhagwandin and G. H. Caughey. Mouse prostasin gene structure,
promoter analysis, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol 30:519-529,
2004.
Wang, X. F., M. M. Reddy and P. M. Quinton. Effects of a new cystic fibrosis transmembrane
conductance regulator inhibitor on Cl- conductance in human sweat ducts. Exp Physiol 89:417-425,
2004.
Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. HO-1 induction restores c-AMP-
dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J. 19:287-9, 2004
Salinas, DB, Pedemonte N, Muanprasat C, Finkbeiner WR, Nielson DW, Verkman AS. CFTR
involvement in nasal potential differences in mice an pigs studied using a thiazolidinone CFTR inhibitor,
Am J Physiol 287:L936-43, 2004
Salinas, D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS.
Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 19:431-3, 2004
Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D MA, Canessa CM, Pittet JF. Interleukin-
1beta decreases expression of the epithelial sodium channel alpha-submit in alveolar epithelial cells via
a p38 MAPK- dependent signaling pathway. J Biol Chem. 280:18579-89, 2005
Pittet, JF, Lee H, Pespeni M, O’Mahony A, Roux J, Welch. Stress-induced inhibition of the NF-kappaB
signaling pathway results from the insolubilization of the IkappaB kinase complex following its
dissociation from heat shock protein 90. J Immunol. 174:384-94, 2005
Wang X, Lytle C, Quinton PM. Predominant constitutive CFTR conductance in small airways. Respir
Res 6:7 (12pp), 2005
In August of 2003, Cystic Fibrosis Research, Inc. (www.cfri.org) re-named their fellowship program to
honor Liz, her work in CF research, and her service as chairperson of the CFRI research advisory
committee. The Elizabeth Nash Memorial Fellowship program is designed to encourage post-doctoral
fellows to pursue careers in CF research and is awarded annually to scientists in the San Francisco
Bay Area. A list of papers published to date through this funding is included below.
Publications Resulting from Funding via CFRI's Elizabeth Nash Memorial Fellowship
Chandy, G., M. Grabe, H. P. Moore and T. E. Machen. Proton leak and CFTR in regulation of Golgi pH
in respiratory epithelial cells. Am J Physiol Cell Physiol 281:C908-921, 2001.
Machen, T. E., G. Chandy, M. Wu, M. Grabe and H. P. Moore. Cystic fibrosis transmembrane
conductance regulator and H+ permeability in regulation of Golgi pH. Jop 2:229-236, 2001.
Jacob, T., R. J. Lee, J. N. Engel and T. E. Machen. Modulation of cytosolic Ca(2+) concentration in
airway epithelial cells by Pseudomonas aeruginosa. Infect Immun 70:6399-6408, 2002.
Howard, M., H. Fischer, J. Roux, B. C. Santos, S. R. Gullans, P. H. Yancey and W. J. Welch.
Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane
conductance regulator (CFTR) protein maturation and function. J Biol Chem 278:35159-35167, 2003.
Frank, J., J. Roux, H. Kawakatsu, G. Su, A. Dagenais, Y. Berthiaume, M. Howard, C. M. Canessa, X.
Fang, D. Sheppard, M. A. Matthay and J. F. Pittet. Transforming growth factor-beta1 decreases
expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid
transport via an ERK1/2-dependent mechanism. J Biol Chem 278:43939-43950, 2003.
Swanson, B., R. Savel, F. Szoka, T. Sawa and J. Wiener-Kronish. Development of a high throughput
Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods 52:361-366, 2003.
Chen, Y., Y. H. Zhao, T. B. Kalaslavadi, E. Hamati, K. Nehrke, A. D. Le, D. K. Ann and R. Wu.
Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular
tissues. Am J Respir Cell Mol Biol 30:155-165, 2004.
Fischer, H., C. Schwarzer and B. Illek. Vitamin C controls the cystic fibrosis transmembrane
conductance regulator chloride channel. Proc Natl Acad Sci U S A 101:3691-3696, 2004.
Schwarzer, C., T. E. Machen, B. Illek and H. Fischer. NADPH oxidase-dependent acid production in
airway epithelial cells. J Biol Chem 21:21, 2004.
Tong, Z., B. Illek, V. J. Bhagwandin, G. M. Verghese and G. H. Caughey. Prostasin, a membrane-
anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway
epithelial cell line. Am J Physiol Lung Cell Mol Physiol 9:9, 2004.
Verghese, G. M., Z. Y. Tong, V. Bhagwandin and G. H. Caughey. Mouse prostasin gene structure,
promoter analysis, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol 30:519-529,
2004.
Wang, X. F., M. M. Reddy and P. M. Quinton. Effects of a new cystic fibrosis transmembrane
conductance regulator inhibitor on Cl- conductance in human sweat ducts. Exp Physiol 89:417-425,
2004.
Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. HO-1 induction restores c-AMP-
dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J. 19:287-9, 2004
Salinas, DB, Pedemonte N, Muanprasat C, Finkbeiner WR, Nielson DW, Verkman AS. CFTR
involvement in nasal potential differences in mice an pigs studied using a thiazolidinone CFTR inhibitor,
Am J Physiol 287:L936-43, 2004
Salinas, D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS.
Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 19:431-3, 2004
Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D MA, Canessa CM, Pittet JF. Interleukin-
1beta decreases expression of the epithelial sodium channel alpha-submit in alveolar epithelial cells via
a p38 MAPK- dependent signaling pathway. J Biol Chem. 280:18579-89, 2005
Pittet, JF, Lee H, Pespeni M, O’Mahony A, Roux J, Welch. Stress-induced inhibition of the NF-kappaB
signaling pathway results from the insolubilization of the IkappaB kinase complex following its
dissociation from heat shock protein 90. J Immunol. 174:384-94, 2005
Wang X, Lytle C, Quinton PM. Predominant constitutive CFTR conductance in small airways. Respir
Res 6:7 (12pp), 2005
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Elizabeth Nash Foundation
PO Box 1260
Los Gatos, CA 95031-1260
PO Box 1260
Los Gatos, CA 95031-1260
| DEDICATED TO IMPROVING THE LIVES OF THOSE AFFECTED BY CYSTIC FIBROSIS |
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CF Research: